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New study published in Nature Microbiology gives first insights into the microbial community-wide transcriptional interactions

Clinical-Microbiomics is proud to announce the publication of the largest gene expression study of the human gut microbiome to date. 

The study was done by integrating metagenomics and metatranscriptomics data, describing the expression of over 700.000 genes from hundreds of bacterial species, and the results suggest that regulation of gene expression plays an important role in species adaptation to coexistence. The study was conducted at Technical University of Denmark and lead by our CSO, Henrik Bjørn Nielsen.

Damian Plichta, first-author of the paper and Director of Bioinformatics at Clinical-Microbiomics, describes the significance of the study: “Mapping of the transcriptional interactions among the microbiome species is important for our understanding of the interplay between gut bacteria, and may be important for understanding certain diseases. We see that many bacteria change the way they behave depending on which other bacteria species are present in our gut. Furthermore, if you want to introduce probiotics to the gut it is important to understand exactly how these interplay with the other bacteria in the gut. Our study shows how we can investigate probiotics impact on the activities in microbiome in the future”.

The results was published in Nature Microbiology (August 26, 2016,


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