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Breakthrough microbiomics platform offers cost-efficient imputed whole-genome metagenomics and strain-level analyses

Clinical-Microbiomics, a specialized microbiome analyses provider and developer of advanced bioinformatics tools, announces a new metagenomics platform for microbiome systems biology that significantly reduces the cost of comprehensive whole-genome metagenomics profiling by imputation from shallow sequencing, and enables de novo strain-level microbiome profiling.   

The platform is built on knowledge learned from an unprecedented collection of more than 2000 deep-sequenced human gut samples and the pioneering metagenomics species (MGS) concept (Nielsen et al., Nature Biotechnology, 2014). The MGS concept relies on de novo species identification and captures up to 80% of the microbial diversity in the samples compared to most reference-based methods that capture just 25% of the diversity at species level.

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Gubra and Clinical-Microbiomics Announces Pre-clinical Microbiome Partnership

Two renowned research companies – one focused on preclinical research and discovery, the other on tailored microbiomic analysis – team up in order to help uncover the microbiomic components of diabetes, obesity and NAFLD/NASH

Hørsholm, August 29, 2016 – Gubra ApS and Clinical-Microbiomics A/S announced today a strategic partnership focusing on analyzing the role of the microbiome in conditions related to diabetes, obesity and NAFLD/NASH. The combined expertise and resources of these two world-leading research companies will enable a fast and customer tailored pre-clinical assessment of the impact of drugs and diet on the gut microbiome.

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New study published in Nature Microbiology gives first insights into the microbial community-wide transcriptional interactions

Clinical-Microbiomics is proud to announce the publication of the largest gene expression study of the human gut microbiome to date. 

The study was done by integrating metagenomics and metatranscriptomics data, describing the expression of over 700.000 genes from hundreds of bacterial species, and the results suggest that regulation of gene expression plays an important role in species adaptation to coexistence. The study was conducted at Technical University of Denmark and lead by our CSO, Henrik Bjørn Nielsen.

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